ÌÇÐÄvlogÊÓƵ

Professor Jonathan Elliott

MA, Vet MB, PhD, Cert SAC, Dip ECVPT, MRCVS
Professor of Veterinary Clinical Pharmacology

Department: Comparative Biomedical Sciences

Campus: Camden

Research Groups: Cardiovascular and Renal Biology, Brain Health and Behaviour, CPCS (Research Programme)

Jonathan Elliott is Professor of Veterinary Clinical Pharmacology and has been an academic at the ÌÇÐÄvlogÊÓƵ for approaching 32 years.  For 16 of these he served as Vice Principal for Research and Innovation, taking responsibility the RVC’s for research strategy and preparing three consecutive research excellence framework submissions on behalf of the RVC (RAE2008, REF2014 and REF2021).  He stepped down from the VP role on 31st March 2021 after submitting REF2021 and has just returned from a 12 month sabbatical to resume his academic duties in the Department of Comparative Biomedical Sciences.  

Jonathan Elliott graduated from Cambridge University Veterinary School in 1985. After graduation, he completed an Internship at Veterinary Hospital University of Pennsylvania in Philadelphia in 1986, a PhD in vascular biology and amine oxidases at the University of Cambridge in 1989 and gained his RCVS Certificate in Small Animal Cardiology in 1990.

In 1990 he was appointed to a lectureship at the ÌÇÐÄvlogÊÓƵ in London where he is currently Professor in Veterinary Clinical Pharmacology.  He served as Vice Principal – Research and Innovation for over 16 years (2004-2021) leading the RVC’s submissions for RAE2008, REF 2014 and REF 2021. He was awarded the Pfizer Academic Award (1998) for his research contributions to the pathophysiology of laminitis and the BSAVA Amoroso award (2001), the PetPlan Scientific Award (2005), the European Society of Nephrology and Urology Award (2007) and the BSAVA Woodrow Award (2019), all for his clinical research contributions in the area of feline chronic kidney disease. He is a Diplomate of the European College of Veterinary Pharmacology and Toxicology.  He is currently President of ECVPT (2018-2021) and is a member of the International Renal Interest Society.  He also chairs the Petplan Charitable Trust Scientific Committee and is a panel member of the UKRI Future Leaders Fellowship scheme.

Professor Elliott is currently a member of:

Professor Elliott is a past member of  and BBSRCs Training Awards Committee 

Jonathan's research interests encompass the pathophysiology of renal, cardiac and vascular diseases of companion animals. He belongs to the Comparative Physiology & Clinical Sciences research programme.

Orcid ID: 

Finding, Elizabeth J. T.; Elliott, Jonathan; Harris, Patricia A.; Menzies-Gow, Nicola J. 

Research In Veterinary Science (2022)

 

Elliott, J; Geddes RF

The Veterinary Journal (2022).  

Tang, P-K; Geddes, RF; Jepson, RE; Elliott, J

The Veterinary Journal, 275: 105719: July 2021

Geddes RF, van den Broek DHN, Chang YM, Biourge V, Elliott J, Jepson RE.
 
J Vet Intern Med. 2021 Mar;35(2):997-1007.

Wilshaw J, Stein M, Lotter N, Elliott J, Boswood A
 
J Small Anim Pract. 2021 Jun;62(6):428-436.

Foth S, Meller S, Kenward H, Elliott J, Pelligand L, Volk HA.

BMC Vet Res. 2021 Jun 21;17(1):222. 

Wilshaw J, Rosenthal SL, Wess G, Dickson D, Bevilacqua L, Dutton E, Deinert M, Abrantes R, Schneider I, Oyama MA, Gordon SG, Elliott J, Xia D, Boswood A.

J Vet Intern Med. 2021 Mar;35(2):755-770.

Coltherd JC, Alexander JE, Pink C, Rawlings J, Elliott J, Haydock R, Carvell-Miller LJ, Biourge VC, Molina L, Butterwick R, Logan DW, Watson P, Bakke AM

Br J Nutr. 2021 Feb 8:1-16.

Enache AE, Dietrich UM, Drury O, Trucco E, MacGillivray T, Syme H, Elliott J, Chang YM.

J Feline Med Surg. 2021 Mar 19:1098612X21997629. 

Tang PK, Geddes RF, Chang YM, Jepson RE, Bijsmans E, Elliott J.

J Vet Intern Med. 2021 Jan;35(1):321-332. 

Lawson JS, Syme HM, Wheeler-Jones CPD, Elliott J. 
 Vet J. 2021 Jan;267:105582. doi: 10.1016/j.tvjl.2020.105582. (2021)

Sargent HJ, Elliott J, Jepson RE.
 J Small Anim Pract. 2021 Feb;62(2):71-81. doi: 10.1111/jsap.13236

Biourge V, Delmotte S, Feugier A, Bradley R, McAllister M, Elliott J

J Vet Intern Med. 2020 Sep 7;34(5):1920-31

Pelligand L, Guillot E, Geneteau A, Guyonnet J, Magnier R, Elliott J, Peyrou M, Jacobs M.
.  Front Vet Sci. 2020 Apr 28;7:151. doi: 10.3389/fvets.2020.00151. eCollection 2020.

McKenna, M; Pelligand, L; Elliott, J; Cotter, D; Jepson, R

Journal of Veterinary Internal Medicine.  2019.  

McKenna, M; Pelligand, L; Elliott, J; Walker, D; Jepson, R

Journal of Veterinary Internal Medicine. 2019

Lawson, J S; Syme, H M; Wheeler-Jones, C P D; Elliott, J.
.
RESEARCH IN VETERINARY SCIENCE, 12799-102. 2019

Bradley, R; Tagkopoulos, I; Kim, M; Kokkinos, Y; Panagiotakos, T; Kennedy, J; De Meyer, G; Watson, P; Elliott, J.
.
Journal of Veterinary Internal Medicine, 2019

Sargent, H J; Jepson, R E; Chang, Y-M; Biourge, V C; Bijsmans, E S; Elliott, J.

Journal of Veterinary Internal Medicine, 2019

Suokko, M; Saloranta, L; Lamminen, T; Laine, T; Elliott, J.

VETERINARY RECORD, 2019

Al-Agele, R; Paul, E; Taylor, S; Watson, C; Sturrock, C; Drakopoulos, M; Atwood, R C; Rutland, C S; Menzies-Gow, N J; Knowles, E; Elliott, J; Harris, P; Rauch, C.
.
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2019

Conroy, M C; Brodbelt, D C; O'Neill, D G; Chang, Y M; Elliott, J.

VETERINARY RECORD, 2019

Covey, H L; Chang, Y M; Elliott, J; Syme, H M.
.
Journal of Veterinary Internal Medicine, 2019

Pelander, L; Häggström, J; Larsson, A; Syme, H M; Elliott, J; Heiene, R; Ljungvall, I.
.
Journal of Veterinary Internal Medicine, 2019

Glaus, T M; Elliott, J; Herberich, E; Zimmering, T; Albrecht, B.

Journal of Veterinary Internal Medicine, 33;2:413-422. 2019

Pelander, L; Brunchault, V; Buffin-Meyer, B; Klein, J; Breuil, B; Zürbig, P; Magalhães, P; Mullen, W; Elliott, J; Syme, H; Schanstra, J P; Häggström, J; Ljungvall, I.

VETERINARY JOURNAL, 24973-79.  2019

Alexander, J; Stockman, J; Atwal, J; Butterwick, R; Colyer, A; Elliott, D; Gilham, M; Morris, P; Staunton, R; Renfrew, H; Elliott, J; Watson, P.

BRITISH JOURNAL OF NUTRITION, 211-21, 2018

Finch, N; Syme, H M; Elliott, J.
.
Journal of Veterinary Internal Medicine, 2018

Conroy, M; Chang, Y-M; Brodbelt, D; Elliott, J.
.
Journal of Veterinary Internal Medicine, 1-10.  2018

Timpson, A; De Mestre, A M; Elliott, J; Harris, P A; Cheng, Z; Mirczuk, S M; Callan, L; Rainbow, L; Menzies-Gow, N J.
.
Journal of Equine Veterinary Science, 2018

Finding, E J T; Lawson, C; Elliott, J; Harris, P A; Menzies-Gow, N J.
.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,.
2018

Geddes, R F; Jepson, R E; Forcada, Y; Elliott, J; Syme, H M.
.
VETERINARY JOURNAL, 23534-41. (2018)

Van Den Broek, D H N; Chang, Y-M; Elliott, J; Jepson, R E.

JOURNAL OF VETERINARY INTERNAL MEDICINE, (2018)

Van Den Broek, D H N; Geddes, R F; Williams, T L; Chang, Y-M; Elliott, J; Jepson, R E.
.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32;2:727-735. (2018)

Lawson, J S; Syme, H M; Wheeler-Jones, C P D; Elliott, J.

BMC Veterinary Research, 14; 76. (2018)

Lawson, J S; Liu, H-H; Syme, H M; Purcell, R; Wheeler-Jones, C P D; Elliott, J.

PLoS One, 13;8:e0202577. 2018

Knowles, E J; Moreton-Clack, M C; Shaw, S; Harris, P A; Elliott, J; Menzies-Gow, N J.
.
EQUINE VETERINARY JOURNAL, (2017)

Knowles, E J; Harris, P A; Elliott, J; Menzies-Gow, N J.
.
EQUINE VETERINARY JOURNAL, 49;4:519-524. (2017)

Hezzell, M J; Boswood, A; Lopez-Alvarez, J; Lotter, N S; Elliott, J.
.
Journal of Veterinary Cardiology, 19;4:325-328. (2017)

Menzies-Gow NJ, Harris PA, Elliott J. 
 
Equine Vet J. 2017 May;49(3):300-306.

Kenward, H; Elliott, J; Lee, T; Pelligand, L.

BMC Veterinary Research, 13;1:244. (2017)

Williams, T L; Elliott, J; Syme, H M; Archer, J.
.
RESEARCH IN VETERINARY SCIENCE, 115; 412-417. (2017)

Crossley, V J; Debnath, A; Chang, Y M; Fowkes, R; Elliott, J; Syme, H.

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31; 4; 1028-1034; (2017)

Van Den Broek, H; Chang, Y M; Elliott, J; Jepson, R E.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2017)

Bijsmans, E S; Doig, M; Jepson, R E; Syme, H M; Elliott, J; Pelligand, L.
.
JOURNAL OF VETERINARY INTERNAL MEDICINE, (2016).

Brown, C; Elliott, J; Schmiedt, C; Brown, S.
.
VETERINARY PATHOLOGY, 2016. 53;2:309-326.

Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB. . J Small Anim Pract. 2016 Nov;57(11):580-588.

Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. . CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635.

Cowgill LD, Polzin DJ, Elliott J, Nabity MB, Segev G, Grauer GF, Brown S, Langston C, van Dongen AM.    Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):995-1013.

Vaden SL, Elliott J.  .  Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1115-30.

Sanchez-Lara, AC; Elliott, J; Syme, HM; Brown, CA; Haylor, JL.  Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme.
VETERINARY PATHOLOGY, 2015, 52;3:513-523. 

Lawson J, Elliott J, Wheeler-Jones C, Syme H, Jepson R.  Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. Vet J. 2015 Jan;203(1):18-26.

Kenward H, Pelligand L, Savary-Bataille K, Elliott J. Nausea: current knowledge of mechanisms, measurement and clinical impact. Vet J. 2015 Jan;203(1):36-43. 

Lees P, Pelligand L, Elliott J, Toutain PL, Michels G, Stegemann M. Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review. J Vet Pharmacol Ther. 2015 Feb;38(1):1-14.  

Finch NC, Heiene R, Elliott J, Syme HM, Peters AM. Determination of extracellular fluid volume in healthy and azotemic cats. J Vet Intern Med. 2015 Jan;29(1):35-42. 

Bijsmans, E S; Jepson, R E; Chang, Y M; Syme, H M; Elliott, J.
.
Journal of Veterinary Internal Medicine, 29;3:855-61. (2015).

Chetboul, V; Reynolds, BS; Trehiou-Sechi, E; Nguyen, P; Concordet, D; Sampedrano, CC; Testault, I; Elliott, J; Abadie, J; Biourge, V; Lefebvre, HP. (2014)
Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.
PLoS One, 9;6:e97862.

Lopez-Alvarez, J; Boswood, A; Moonarmart, W; Hezzell, M J; Lotter, N; Elliott, J. (2014)
Longitudinal Electrocardiographic Evaluation of Dogs with Degenerative Mitral Valve Disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28;2:393-400.

Kenward, H; Pelligand, L; Elliott, J. (2014)
Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.
EXPERIMENTAL BRAIN RESEARCH
   [Epub ahead of print]

Menzies-Gow, N J; Wray, H; Bailey, S R; Harris, P A; Elliott, J. (2014)
The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies.
EQUINE VETERINARY JOURNAL, 46;3:317-321.

Jepson RE, Syme HM, Elliott J. (2014)
Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate.
JOURNAL OF VETERINARY INTERNAL MEDICINE. 2014 Jan-Feb;28(1):144-53.

Braff, J; Obare, E; Yerramilli, M; Elliott, J; Yerramilli, M.
.
Journal of Veterinary Internal Medicine, 28;6:1699-1701. (2014)

Williams, TL; Elliott, J; Syme, HM. (2013)
Renin-Angiotensin-Aldosterone System Activity in Hyperthyroid Cats with and without Concurrent Hypertension..
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:522-529.
http://dx.doi.org/10.1111/jvim.12062

Reynolds, B S; Chetboul, V; Nguyen, P; Testault, I; Concordet, D V; Sampedrano, C C; Elliott, J; Trehiou-Sechi, E; Abadie, J; Biourge, V; Lefebvre, H P. (2013)
Effects of Dietary Salt Intake on Renal Function: A 2-Year Study in Healthy Aged Cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:507-515.
http://dx.doi.org/10.1111/jvim.12074

Finch, N C; Geddes, R F; Syme, H M; Elliott, J.

Journal of Veterinary Internal Medicine, 27;2:227-33. (2013)

O'Neill, DG; Elliott, J; Church, DB; McGreevy, PD; Thomson, PC; Brodbelt, DC (2013)
Chronic Kidney Disease in Dogs in UK Veterinary Practices: Prevalence, Risk Factors, and Survival
JOURNAL OF VETERINARY INTERNAL MEDICINE.  http://dx.doi.org/10.1111/jvim.12090

Finch N. C.; Syme H. M.; Elliott J. (2012)
Association of urinary cadmium excretion with feline hypertension
VETERINARY RECORD 170 (5), 125-U47 DOI: 10.1136/vr.100264

Pelligand L.; King J. N.; Toutain P. L.; Elliott, J; Lees, P (2012)
Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 35 (1): 19-32
DOI: 10.1111/j.1365-2885.2011.01288.x

Finch, NC; Syme, HM; Elliott, J; Peters, AM; Gerritsen, R; Croubels, S; Heine, R (2012)
Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats
Source: AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (12): 1652-1659


Wakeling, J; Elliott, J; Syme, H (2011)
Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE 25(5): 1057-1065
DOI: 10.1111/j.1939-1676.2011.00790.x


Jones, ID; Fuentes, VL; Wrigglesworth, D; Mort, E; Elliott, J (2011)
Comparison of flow-mediated vasodilation in femoral and brachial arteries in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH 72(8): 1029-1037


Pelligand, L; Lees, P; Elliott, J (2011)
Development and validation of a timed urinary collection system for use in the cat
LABORATORY ANIMALS 45 (3): 196-203 DOI: 10.1258/la.2011.

Katz, LM: Marr, CM; Elliott, J (2011)
Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide
AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (7): 975-981


BROOKS, A.C.; MENZIES-GOW, N.J.; WHEELER-JONES, C.P.D.; BAILEY, S.R.; ELLIOTT, J.; CUNNINGHAM, F.M. (2009)  Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases.  J vet Pharmacol Therap 32, 189-196. 

JEPSON, R E; BRODBELT, D C; VALLANCE, C; SYME, H E; ELLIOTT, J
.
Journal of Veterinary Internal Medicine, 23;4:806-813.
2009

WAKELING, J., MOORE, K., ELLIOTT, J. & SYME, H. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract 49, 287-294.

MENZIES-GOW, N. J., SEPULVEDA, M. F., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2008) Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. Am J Vet Res 69, 199-207.

MENZIES-GOW, N. J., BAILEY, S. R., BERHANE, Y., BROOKS, A. C. & ELLIOTT, J. (2008) Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. Am J Vet Res 69, 349-355.

BERHANE, Y., BAILEY, S. R., PUTIGNANO, C. & ELLIOTT, J. (2008) Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit. J Vet Pharmacol Ther 31, 1-8.

BAILEY, S. R., HABERSHON-BUTCHER, J. L., RANSOM, K. J., ELLIOTT, J. & MENZIES-GOW, N. J. (2008) Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 69, 122-129.

JEPSON, R E; SYME, H M; VALLANCE, C; ELLIOTT, J
.
Journal of Veterinary Internal Medicine, 22;2:317-324. (2008)

ZERPA, H., BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2007) Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. Eur J Pharmacol 569, 212-221.

SYME, H. M., FLETCHER, M. G., BAILEY, S. R. & ELLIOTT, J. (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48, 202-208.

BROOKS, A. C., MENZIES-GOW, N. J., WHEELER-JONES, C., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2007) Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflamm Res 56, 154-161.

BAILEY, S. R., MENZIES-GOW, N. J., HARRIS, P. A., HABERSHON-BUTCHER, J. L., CRAWFORD, C., BERHANE, Y., BOSTON, R. C. & ELLIOTT, J. (2007) Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J Am Vet Med Assoc 231, 1365-1373.

BAILEY, S. R. & ELLIOTT, J. (2007) The corticosteroid laminitis story: 2. Science of if, when and how. Equine Vet J 39, 7-11.

ZERPA, H., BAILEY, S. R., BERHANE, Y. & ELLIOTT, J. (2006) Pharmacological characterization of alpha1-adrenoceptors in equine digital veins. J Vet Pharmacol Ther 29, 55-61.

SYME, H. M., MARKWELL, P. J., PFEIFFER, D. & ELLIOTT, J. (2006) Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J Vet Intern Med 20, 528-535.

ELLIOTT, J. & SYME, H. M. (2006) Proteinuria in chronic kidney disease in cats--prognostic marker or therapeutic target? J Vet Intern Med 20, 1052-1053.

ELLIOTT, J. & BAILEY, S. R. (2006) Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis. J Nutr 136, 2103S-2107S.

BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2006) Assessment of endothelium-dependent vasodilation in equine digital resistance vessels. J Vet Pharmacol Ther 29, 387-395.

MENZIES-GOW, N. J., BAILEY, S. R., STEVENS, K., KATZ, L., ELLIOTT, J. & MARR, C. M. (2005) Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses. Am J Vet Res 66, 630-636.

BOTHAM, K. M., BRAVO, E., ELLIOTT, J. & WHEELER-JONES, C. P. (2005) Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: implications for atherosclerosis development. Curr Pharm Des 11, 3681-3695.

Jonathan teaches renal physiology (BSc year 1) and aspects of pharmacology (BVetMed years 2, 3, 4 and 5; BSc year 2).  He is a tutor to BVetMed students in years 1 and 2.

  • Feline Chronic Kidney Disease Research

    Kidneys filter the blood and produce urine and so problems with kidney function can result in a variety of health problems for a cat. Chronic kidney disease (CKD) is the persistent loss of kidney function over a period of time. CKD is the most common kidney disease affecting cats as they get older. The ÌÇÐÄvlogÊÓƵ’s Geriatric Cat Clinic was established in 1992 with the aim of researching the common conditions of older cats and to help with the care and medical management of the cats that attend the clinic.

  • Researching Laminitis Risks for Horses and Ponies

    A four year study of laminitis in ponies, measuring physical, metabolic and management data, identifying significant factors associated with laminitis such as basal serum insulin concentration, insulin concentration in response to the OST, basal plasma adiponectin concentration and the presence of divergent hoof growth rings on the feet, and making recommendations for treatment  based on this.

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